Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Benzyloxy)-5-bromobenzaldehyde → (2-(Benzyloxy)-5-bromophenyl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Benzyloxy)-5-bromobenzaldehyde | HCID 733087 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (2-(Benzyloxy)-5-bromophenyl)methanol | HCID 897136 | 98.6% |
반응 단계
Sodium borohydride (339 mg, 8.93 mmol) was added to a solution of 2-benzyloxy-5-bromo-benzaldehyde (2.6 g, 8.93 mmol) in anhydrous ethanol (20 mL) at 0° C. The reaction was allowed to warm to room temperature and, after 3 hours, the mixture was concentrated and the residue was dissolved in ethyl acetate (50 mL) and washed with water (1×25 mL), 1N HCl solution (1×25 mL) and brine (1×25 mL). The solution was dried (Na2SO4), filtered and concentrated. The residue was purified by flash chromatography (8% ethyl acetate/hexane) to afford 2.58 g of the title compound as a colorless oil (98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06803457B1 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-8da6b060110d420c939cce3163a83cf8 |
| 출처 메모 | uspto-grants-2004_10 |