Phosgene → HCID 58355784, 화합물

HRID 39298노트

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HRID 39298 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([OH:14])([CH3:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15](Cl)([Cl:17])=[O:16]>C1COCC1.C1(C)C=CC=CC=1>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([O:14][C:15]([Cl:17])=[O:16])([CH3:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 6371PhosgeneHCID 22951485tert-Butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate

생성물 1

HCID 58355784HCID 58355784, 화합물

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-hydroxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester (200 mg, 1.00 mmol) in THF (4 mL) was slowly treated with phosgene 20% in toluene (0.954 mL). After stirring at rt for 16 h, solvents were removed under reduced pressure and co-evaporate with CH2Cl2. The crude 3-chlorocarbonyloxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester was used directly in the next step.

후처리

  1. customsolvents were removed under reduced pressure and co-evaporate with CH2Cl2

출처 및 근거

ORD 기록
ord-3ec82e7f4b7340b6b11e56dfb62d773e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524764B2

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