Formic Acid → HCID 136388388, 화합물

HRID 393245노트

반응식

HRID 393245 반응식
[NH2:1][C:2]1[C:11]([C:12](=[O:14])[NH2:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([OH:15])[CH:3]=1.[CH:16](O)=O>>[OH:15][C:4]1[CH:3]=[C:2]2[C:11]([C:12](=[O:14])[NH:13][CH:16]=[N:1]2)=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 22649192HCID 22649192, 화합물

생성물 1

HCID 136388388HCID 136388388, 화합물

실험 절차

A mixture of methyl 4-amino-5-carbamoyl-2-hydroxybenzoate (5.4 g) and formic acid (50 ml) was heated to reflux for 1 hour. The mixture was evaporated. Toluene (75 ml) was added and the mixture was evaporated. The solid residue was washed with methanol and diethyl ether and dried to give methyl 7-hydroxy-4-oxo-3,4-dihydroquinazolin-6-carboxylate (5.2 g); NMR Spectrum: (DMSOd6) 4.9 (s, 3H), 7.09 (s, 1H), 7.39 (s, 1H), 8.5 (s, 1H).

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. customThe mixture was evaporated
  4. additionToluene (75 ml) was added
  5. customthe mixture was evaporated
  6. washThe solid residue was washed with methanol and diethyl ether
  7. customdried

출처 및 근거

ORD 기록
ord-850cabeb028b4b338e7ad34e2df0c418
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06806274B1

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