Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Boc-p-toluenesulfonamide → tert-Butyl methyl(tosyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Boc-p-toluenesulfonamide | HCID 688170 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | tert-Butyl methyl(tosyl)carbamate | HCID 22660067 | 85% |
반응 단계
The crude fluorous DEAD reagent 22 was then used in Mitsunobu reactions with N-Boc-p-toluenesulfonamide. Once again, the standard mode of addition gave complete conversion with MeOH and the product, N-methyl-N-boc-p-toluenesulfonamide was isolated in 85% yield after FSPE. However, the allyl alcohol gave only trace conversion of the starting material. The organic fraction after FSPE was mostly starting material. These results are summarized in Table 7.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06806357B1 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-41a99d97be5e482e8c5bb07a1cfdf604 |
| 출처 메모 | uspto-grants-2004_10 |