Methanol → HCID 22646437, 화합물

HRID 393514

반응식

HRID 393514 반응식
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[N+:13]([C:16]1[CH:21]=[CH:20][C:19]([CH:22]([CH2:26][CH3:27])C(O)=O)=[CH:18][CH:17]=1)([O-:15])=[O:14].[CH:28]1[CH:33]=[CH:32][C:31]([NH:34][C:35]2[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=2)=[CH:30][CH:29]=1.CO>C(Cl)Cl>[N+:13]([C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH2:26][CH2:27][C:1]([O:41][C:38]2[CH:39]=[CH:40][C:35]([NH:34][C:31]3[CH:30]=[CH:29][CH:28]=[CH:33][CH:32]=3)=[CH:36][CH:37]=2)=[O:2])=[CH:20][CH:21]=1)([O-:15])=[O:14]

참가 물질

6

반응물 4

HCID 887MethanolHCID 240472-(4-Nitrophenyl)butyric acidHCID 312084-HydroxydiphenylamineHCID 682631,1'-Carbonyldiimidazole

생성물 1

HCID 22646437HCID 22646437, 화합물수율 89%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

0.98 g (6.02 mmol) of 1,1′-carbonyldiimidazole is slowly added at 20° C. to a solution of 1.25 g (5.96 mmol) of 4-nitrophenylbutyric acid in 25 ml CH2Cl2. The reaction mixture is agitated for 30 minutes before the addition of 1 g (5.42 mmol) of 4-hydroxydiphenylamine. After agitation for 3 hours, the reaction is stopped by the addition of 3 ml of MeOH and the solvent is evaporated under vacuum. The evaporation residue is purified on a silica column (eluent: Heptane/AcOEt: 100/0 to 80/20). A yellow solid is obtained with a yield of 89%.

후처리

  1. customthe solvent is evaporated under vacuum
  2. customThe evaporation residue is purified on a silica column (eluent: Heptane/AcOEt: 100/0 to 80/20)
  3. customA yellow solid is obtained with a yield of 89%

출처 및 근거

ORD 기록
ord-5469ec2036f44108a9d2609512fabd9f
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809090B2

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