7-Benzyloxy-4-chloro-6-methoxyquinoline hydrochloride → 4-Chloro-6-methoxyquinolin-7-ol
반응식
Cl.C([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([Cl:20])=[CH:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[Cl:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([OH:9])=[C:11]([O:21][CH3:22])[CH:12]=2)[N:17]=[CH:16][CH:15]=1참가 물질
3
실험 절차
A solution of 7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride (6.8 g, 20 mmol) in TFA (80 ml) was heated at reflux for 5.5 hours. The volatiles were removed by evaporation, the residue suspended in water and the mixture was adjusted to pH7 with a saturated aqueous sodium hydrogen carbonate solution. The resulting solid was collected by filtration, washed with water, ether and dried under vacuum to give 4-chloro-7-hydroxy-6-methoxyquinoline (4.1 g, 98%).
후처리
- temperatureat reflux for 5.5 hours
- customThe volatiles were removed by evaporation
- filtrationThe resulting solid was collected by filtration
- washwashed with water, ether
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-a07b263e1f9c44569f87333c7a7d219b
- 출처 데이터셋
- uspto-grants-2004_10
- 특허 번호
- US06809097B1
반응 노트
불러오는 중…