Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 393600생성일: 2026년 10월 23일
5-Benzyloxy-2-fluoro-4-methylphenol → 4-(5-Benzyloxy-2-fluoro-4-methylphenoxy)-6-methoxy-7-(3-morpholinopropoxy)quinoline
https://huagongshe.com/ko/reaction/393600
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Benzyloxy-2-fluoro-4-methylphenol | HCID 21991049 | — |
| 반응물 | 4-(3-((4-Chloro-6-methoxyquinolin-7-yl)oxy)propyl)morpholine | HCID 22265257 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 4-(5-Benzyloxy-2-fluoro-4-methylphenoxy)-6-methoxy-7-(3-morpholinopropoxy)quinoline | HCID 22646631 | 69% |
반응 단계
4-Chloro-6-methoxy-7-(3-morpholinopropoxy)quinoline (250 mg, 0.74 mmol) was added to a solution of 5-benzyloxy-2-fluoro-4-methylphenol (257 mg 1.1 mmol) and potassium t-butoxide (125 mg, 1.1 mmol) in DMSO (3 ml) and the mixture heated at 160° C. for 1.5 hours. The mixture was allowed to cool and was partitioned between water and ethyl acetate. The organic layer was separated, washed with brine, dried (MgSO4), and the solvent removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 4-(5-benzyloxy-2-fluoro-4-methylphenoxy)-6-methoxy-7-(3-morpholinopropoxy)quinoline (105 mg, 69%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06809097B1 |
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| 출처 데이터셋 | uspto-grants-2004_10 |
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| ORD ID | ord-5a38eee06c30427a9e107d76bcd0c311 |
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| 출처 메모 | uspto-grants-2004_10 |
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