HCID 22646593, 화합물 → 6-Methoxy-7-(3-morpholinopropoxy)quinolin-4-ol
반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[C:13]([CH:26]=[CH:27][C:28]=2[O:29][CH3:30])[NH:14][CH:15]=[C:16]2[C:21](=[O:22])OC(C)(C)OC2=O)[CH2:3][CH2:2]1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:30][O:29][C:28]1[CH:27]=[C:26]2[C:13](=[CH:12][C:11]=1[O:10][CH2:9][CH2:8][CH2:7][N:4]1[CH2:3][CH2:2][O:1][CH2:6][CH2:5]1)[NH:14][CH:15]=[CH:16][C:21]2=[O:22]참가 물질
3
실험 절차
A solution of 5-((3-(3-morpholinopropoxy)-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (700 mg, 1.66 mmol) in phenyl ether (5 ml) was heated at reflux for 2 minutes. After cooling, the residue was triturated with ether and acetone. The solid was collected by filtration, washed with acetone followed by ether and dried under vacuum to give 6-methoxy-7-(3-morpholinopropoxy)-1,4-dihydroquinolin-4-one (207 mg, 41%).
후처리
- temperatureat reflux for 2 minutes
- temperatureAfter cooling