4-Chloro-2-fluoroaniline → HCID 22646544, 화합물

HRID 393640노트

반응식

HRID 393640 반응식
Cl.[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[CH:5][CH:4]=1.[Cl:24][C:25]1[CH:31]=[CH:30][C:28]([NH2:29])=[C:27]([F:32])[CH:26]=1>CC(O)CCC>[ClH:2].[Cl:24][C:25]1[CH:31]=[CH:30][C:28]([NH:29][C:3]2[C:12]3[C:7](=[CH:8][C:9]([O:15][CH2:16][CH2:17][CH2:18][N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)=[C:10]([O:13][CH3:14])[CH:11]=3)[N:6]=[CH:5][CH:4]=2)=[C:27]([F:32])[CH:26]=1

참가 물질

4

반응물 2

HCID 938984-Chloro-2-fluoroanilineHCID 22646629HCID 22646629, 화합물

생성물 1

HCID 22646544HCID 22646544, 화합물수율 44.3%

시약·촉매·용매 1

HCID 223862-Pentanol용매

실험 절차

Using an analogous procedure to that described for Example 15, 4-chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinoline hydrochloride (236 mg, 0.6 mmol), (prepared as described for the starting material in Example 31), was reacted with 4-chloro-2-fluoroaniline (80 μl, 0.72 mmol) in 2-pentanol (5 ml) to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinoline hydrochloride (124 mg, 42%).

후처리

  1. custom(prepared

출처 및 근거

ORD 기록
ord-112b7763e08f4469aca4beb4f37cbc1d
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809097B1

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