Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 393683생성일: 2026년 10월 24일
Urea → 4-(3,5-Bis-trifluoromethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid amide
https://huagongshe.com/ko/reaction/393683
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 반응물 | Acetoacetamide | HCID 80077 | — |
| 반응물 | 3,5-Bis(trifluoromethyl)benzaldehyde | HCID 136247 | — |
| 촉매 | Cupric Chloride | HCID 24014 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(3,5-Bis-trifluoromethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid amide | HCID 86586005 | 36.2% |
반응 단계
A mixture of 3,5-bis(trifluoromethyl)benzaldehyde (2.42 g, 10.0 mmol), acetoacetamide (1.01 g, 10.0 mmol), urea (0.90 g, 15.0 mmol), copper chloride (0.1 g, 1.0 mmol), boron trifluoride etherate (0.09 mL), AcOH (0.04 mL), and THF (20 mL) was heated at 65° C. for 18 h and cooled to room temperature. The resulting precipitates were collected by vacuum filtration, washed with THF, and air dried to give the title compound as an off-white solid(1.33 g, 36%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06809102B2 |
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| 출처 데이터셋 | uspto-grants-2004_10 |
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| ORD ID | ord-b6dad4d14dd3474a9e23c7ce406e1919 |
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| 출처 메모 | uspto-grants-2004_10 |
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