2-Amino-5-bromo-3-methylpyridine → HCID 178422464, 화합물
반응식
N[C:2]1[C:7]([CH3:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.N([O-])=[O:11].[Na+]>OS(O)(=O)=O.O>[Br:9][C:5]1[CH:6]=[C:7]([CH3:8])[C:2]([OH:11])=[N:3][CH:4]=1참가 물질
5
실험 절차
2-Amino-5-bromo-3-methylpyridine (5.0 g, 26.7 mmol) in 2.6M H2SO4 (70 mL) was treated with sodium nitrite (5.0 g, 72.5 mmol) in water (10 mL) dropwise at 0° C. The mixture was allowed to warm to ambient temperature and stir for 1.5 hours. The mixture was filtered and the filtercake washed with cold water. The filtercake was dissolved in dichloromethane (100 mL), dried (MgSO4), and concentrated to provide the title compound (4.2 g, 84% yield). MS (DCI/NH3) M/z 188/190 (M+H)+.
후처리
- filtrationThe mixture was filtered
- washthe filtercake washed with cold water
- dissolutionThe filtercake was dissolved in dichloromethane (100 mL)
- dry with materialdried (MgSO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-b215675b2fac4e29878af11d8c1f0757
- 출처 데이터셋
- uspto-grants-2004_10
- 특허 번호
- US06809105B2
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