참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Fluoroaniline | HCID 9742 | — |
| 반응물 | Diethyl (ethoxymethyl)malonate | HCID 98702 | — |
| 용매 | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| 생성물 | Ethyl 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 178469609 | 67.6% |
반응 단계
Under a nitrogen atmosphere, 3-fluoroaniline (50.0 g, 0.45 mol) and diethyl ethoxymethylmalonate (91 mL, 0.45 mol) were combined and heated at 100° C. for 3 hours. The reaction was allowed to cool to ambient temperature and it solidified. Dowtherm A (200 mL) was added and the reaction mixture was heated at 240° C. for 4 hours. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, washed with hexane and then dried in a vacuum oven to provide 71.5 g of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06809203B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_10 |
|---|
| ORD ID | ord-634289ea48ee4766bd160165ae5e52f6 |
|---|
| 출처 메모 | uspto-grants-2004_10 |
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