HCID 22648055, 화합물 → 7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one

HRID 394191노트

반응식

HRID 394191 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[C:14]2[C:9]=1[CH2:10][N:11]([CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=1)[C:12](=[O:29])[N:13]2[C:21]1[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=1[Cl:28]>C(OCC)(=O)C.[Pd]>[NH2:18][C:16]1[CH:15]=[C:14]2[C:9]([CH2:10][N:11]([CH2:30][C:31]3[CH:32]=[CH:33][C:34]([O:37][CH3:38])=[CH:35][CH:36]=3)[C:12](=[O:29])[N:13]2[C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH:17]=1

참가 물질

4

반응물 1

HCID 22648055HCID 22648055, 화합물

생성물 1

HCID 226480157-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one (20.0 mg, 0.035 mmol) in ethyl acetate (2 mL) was added 10% Pd/C (14.5 mg) under argon. Hydrogen was bubbled through and the reaction mixture was stirred under hydrogen for 1.5 h. The reaction flask was purged with argon. The catalyst was filtered off washing with methanol. The filtrate was concentrated under reduced pressure to yield 7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one. Mass spectrum (ESI) 538.2 (M+1).

후처리

  1. customHydrogen was bubbled through and the reaction mixture
  2. customThe reaction flask was purged with argon
  3. filtrationThe catalyst was filtered off
  4. washwashing with methanol
  5. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-24019290c15a4b149a4c025ae146158f
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809199B2

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