Morpholine → N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]-3-morpholin-4-ylpropane-1-sulfonamide

HRID 394199노트

반응식

HRID 394199 반응식
Cl[CH2:2][CH2:3][CH2:4][S:5]([NH:8][C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][N:14]([CH2:28][C:29]3[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=3)[C:15](=[O:27])[N:16]2[C:19]2[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:26])=[C:11]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[Cl:43])[CH:10]=1)(=[O:7])=[O:6].[NH:44]1[CH2:49][CH2:48][O:47][CH2:46][CH2:45]1>C(OCC)(=O)C>[Cl:43][C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=1[C:11]1[CH:10]=[C:9]([NH:8][S:5]([CH2:4][CH2:3][CH2:2][N:44]2[CH2:49][CH2:48][O:47][CH2:46][CH2:45]2)(=[O:6])=[O:7])[CH:18]=[C:17]2[C:12]=1[CH2:13][N:14]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)[C:15](=[O:27])[N:16]2[C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[Cl:26]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 22647935HCID 22647935, 화합물

생성물 1

HCID 22648174N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]-3-morpholin-4-ylpropane-1-sulfonamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3chloro-N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]propane-1-sulfonamide (93 mg, 0.14 mmol) in morpholine (0.25 mL) was heated at 130° C. for 45 min. The reaction mixture was cooled to rt, diluted with ethyl acetate, washed with water, dried (Na2SO4), and concentrated under reduced pressure. The product was purified by flash chromatography on a Biotage 40S column, eluting with 60:40 hexanes-acetone to yield N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]-3-morpholin-4-ylpropane-1-sulfonamide. Mass spectrum (ESI) 729 (M+1).

후처리

  1. washwashed with water
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated under reduced pressure
  4. customThe product was purified by flash chromatography on a Biotage 40S column
  5. washeluting with 60:40 hexanes-acetone

출처 및 근거

ORD 기록
ord-6d732f5085a642e686ea0141c7061109
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809199B2

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