Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | trans-(4-Pyrrolidin-1-yl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester | HCID 67358972 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride | HCID 67360004 | — |
반응 단계
trans-(4-Pyrrolidin-1-yl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (intermediate H, 345 mg, 1.28 mmol) was dissolved in 6.4 mL dioxane. Hydrochloric acid (4N in dioxan, 3.2 mL, 13 mmol) was added. The reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated off. The crude material, light brown solid (378 mg, >100%), MS: m/e=171.2 [(M+H)+] was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524909B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-fea28dbce15a4b2aa7955dfd9fe63643 |
| 출처 메모 | uspto-grants-2013_09 |