Hydrochloric Acid → 4-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride

HRID 39422

반응식

HRID 39422 반응식
C(OC(=O)[NH:7][C@H:8]1[C@H:13]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:12][CH2:11][O:10][CH2:9]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:14]1([CH:13]2[CH2:12][CH2:11][O:10][CH2:9][CH:8]2[NH2:7])[CH2:15][CH2:16][CH2:17][CH2:18]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67358972HCID 67358972, 화합물2회

생성물 1

HCID 673600044-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

trans-(4-Pyrrolidin-1-yl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (intermediate H, 345 mg, 1.28 mmol) was dissolved in 6.4 mL dioxane. Hydrochloric acid (4N in dioxan, 3.2 mL, 13 mmol) was added. The reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated off. The crude material, light brown solid (378 mg, >100%), MS: m/e=171.2 [(M+H)+] was used without further purification.

후처리

  1. customThe solvent was evaporated off
  2. customThe crude material, light brown solid (378 mg, >100%), MS: m/e=171.2 [(M+H)+] was used without further purification

출처 및 근거

ORD 기록
ord-fea28dbce15a4b2aa7955dfd9fe63643
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524909B2

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