Aluminium lithium hydride → 3-(2-Phenyl-thiazol-4-yl)-propan-1-ol

HRID 394276

반응식

HRID 394276 반응식
C([O:3][C:4](=O)[CH2:5][CH2:6][C:7]1[N:8]=[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:10][CH:11]=1)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[C:12]1([C:9]2[S:10][CH:11]=[C:7]([CH2:6][CH2:5][CH2:4][OH:3])[N:8]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

3

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 686166683-(2-Phenyl-thiazol-4-yl)-propionic acid ethyl ester

생성물 1

HCID 226474953-(2-Phenyl-thiazol-4-yl)-propan-1-ol수율 76%

실험 절차

In analogy of the procedure described in example 12 b], 0.44 g (1.68 mmol) of 3-(2-phenyl-thiazol-4-yl)-propionic acid ethyl ester was reacted with lithium aluminium hydride, yielding 0.28 g of 3-(2-phenyl-thiazol-4-yl)-propan-1-ol as colorless liquid (75.8% of theory).

출처 및 근거

ORD 기록
ord-07277705a0cd4d4985dca79089eb6c04
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809110B2

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