[Rac]-3-(4-benzyloxy-3-fluoro-phenyl)-2-isopropoxy-propionic acid ethyl ester → [Rac]-3-(3-fluoro-4-hydroxy-phenyl)-2-isopropoxy-propionic acid ethyl ester

HRID 394306

반응식

HRID 394306 반응식
[CH2:1]([O:3][C:4](=[O:26])[CH:5]([O:22][CH:23]([CH3:25])[CH3:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[C:9]([F:21])[CH:8]=1)[CH3:2]>[Pd].C1COCC1>[CH2:1]([O:3][C:4](=[O:26])[CH:5]([O:22][CH:23]([CH3:25])[CH3:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([F:21])[CH:8]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 68617305[Rac]-3-(4-benzyloxy-3-fluoro-phenyl)-2-isopropoxy-propionic acid ethyl ester

생성물 1

HCID 68616202[Rac]-3-(3-fluoro-4-hydroxy-phenyl)-2-isopropoxy-propionic acid ethyl ester수율 97.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

0.5 g of 10% palladium on charcoal were added to a solution of 3.7 g of [rac]-3-(4-benzyloxy-3-fluoro-phenyl)-2-isopropoxy-propionic acid ethyl ester (10.26 mmol) in 30 ml of THF and the compound was stirred under an atmosphere of H2, at normal pressure and ambient temperature, until the absorption of gas stopped. After filtration of the catalyst and evaporation of the filtrate, 2.7 g of [rac]-3-(3-fluoro-4-hydroxy-phenyl)-2-isopropoxy-propionic acid ethyl ester were obtained as colorless viscous oil (97.3% of theory).

후처리

  1. filtrationAfter filtration of the catalyst and evaporation of the filtrate

출처 및 근거

ORD 기록
ord-57fc810ee6c24904a01cb61137da40e9
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809110B2

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