Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → HCID 68616040, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | 1,3-Dichloroacetone | HCID 10793 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-Methyl-thiobenzamide | HCID 816810 | — |
| 반응물 | 4-(Chloromethyl)-2-(4-methylphenyl)-1,3-thiazole | HCID 2063596 | — |
| 반응물 | [Rac]-2-ethoxy-3-(3-fluoro-4-hydroxy-phenyl)-propionic acid ethyl ester | HCID 68618019 | — |
| 생성물 | HCID 68616040 | HCID 68616040 | — |
반응 단계
In analogy to the procedure described in example 14 b], [rac]-2-ethoxy-3-(3-fluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (example 7 a]) was reacted with 4-chloromethyl-2-p-tolyl-thiazole (prepared from 4 methyl-thiobenzamide and 1,3-dichloroacetone in analogy to the procedure described in example 4 a]) in the presence of cesium carbonate and potassium iodide to yield [rac]-2-ethoxy-3-[3-fluoro-4-(2-p-tolyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid ethyl ester, which was further saponified in analogy to the procedure described in example 4 e], to yield [rac]-2-ethoxy-3-[3-fluoro-4-(2-p-tolyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid as light yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06809110B2 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-44b43c66bbdf4c568def9ef9250446cb |
| 출처 메모 | uspto-grants-2004_10 |