Methyl heptanoate → 2-[(4-Benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester

HRID 394394

반응식

HRID 394394 반응식
[C:1]([O:9][CH3:10])(=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C([N-]C(C)C)(C)C.[Li+].[CH2:19]([O:26][C:27]1[CH:34]=[CH:33][C:30]([CH:31]=[O:32])=[C:29]([CH3:35])[CH:28]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>O1CCCC1>[CH3:10][O:9][C:1](=[O:8])[CH:2]([CH:31]([C:30]1[CH:33]=[CH:34][C:27]([O:26][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:28][C:29]=1[CH3:35])[OH:32])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

5

반응물 3

HCID 7826Methyl heptanoateHCID 2724682Lithium diisopropylamideHCID 27598062-Methyl 4-benzyloxybenzaldehyde

생성물 1

HCID 686166792-[(4-Benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In analogy to the procedure described in example 125 a], methyl heptanoate was deprotonated with lithium diisopropylamide and reacted with 4-benzyloxy-2-methyl-benzaldehyde in tetrahydrofuran to obtain 2-[(4-benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester as a mixture of two diastereomeric racemates as light yellow oil.

출처 및 근거

ORD 기록
ord-c3eee6e3a1914b60be869ec077ced694
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06809110B2

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