Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-Acetyl-7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 2-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride | HCID 12606904 | — |
| 반응물 | 7-(Morpholine-4-sulfonyl)-1,2,3,4-tetrahydroisoquinoline | HCID 21983663 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-Acetyl-7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | HCID 18176496 | — |
반응 단계
was obtained as described in Example 4A by reacting morpholine with 2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride in the presence of diisopropylamine in THF and by heating with 50% concentrated hydrochloric acid and, after alkaline workup, converted into the corresponding 7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06602867B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-4465e0f4aed34412858468b27119c327 |
| 출처 메모 | uspto-grants-2003_08 |