참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | 1-Bromo-2-Chloroethane | HCID 7849 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Benzyltriethylammonium | HCID 17208 | — |
| 반응물 | 2,2-Difluoro-1,3-benzodioxole-5-acetonitrile | HCID 20311384 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(2,2-Difluorobenzo[D][1,3]dioxol-5-YL)cyclopropanecarbonitrile | HCID 57446150 | — |
반응 단계
Sodium hydroxide (50% aqueous solution, 10 mL) was slowly added to a mixture of crude (2,2-difluoro-benzo[1,3]dioxol-5-yl-acetonitrile, benzyltriethylammonium, chloride (3.00 g, 15.3 mmol), and 1-bromo-2-chloroethane (4.9 g, 38 mmol) at 70° C. The mixture was stirred overnight at 70° C. before the reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate and evaporated to dryness to give crude 1-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonitrile, which was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08524910B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-b5f7da59d0044b58b7f926938dd088e6 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
