Acrylonitrile → 3-(4-Methoxyphenoxy)propanenitrile

HRID 394669노트

반응식

HRID 394669 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[C:10](#[N:13])[CH:11]=[CH2:12]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:12][CH2:11][C:10]#[N:13])=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 7855AcrylonitrileHCID 90154-Methoxyphenol

생성물 1

HCID 1142473-(4-Methoxyphenoxy)propanenitrile

실험 절차

A mixture of 4-methoxyphenol (10 g: 80.5 mmol) and Triton B (2.29 ml:14.5 mmol:0.18 eq.) in acrylonitrile (50 ml) is heated at reflux for 48 hours. After the solvent has been partially removed, the products are extracted with ethyl acetate and washed with water and then with a 6N hydrochloric acid solution. The residual chestnut-brown oil is purified on a flash silica column eluted with an AcOEt/PE gradient.

후처리

  1. temperatureis heated
  2. temperatureat reflux for 48 hours
  3. customAfter the solvent has been partially removed
  4. extractionthe products are extracted with ethyl acetate
  5. washwashed with water
  6. customThe residual chestnut-brown oil is purified on a flash silica column
  7. washeluted with an AcOEt/PE gradient

출처 및 근거

ORD 기록
ord-ddb496f603064baab815722b4982ba8d
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06602903B2

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