Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-[(2-chlorophenyl)methylidene]-3-oxobutanoate → Phthalimidoamlodipine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-[(2-chlorophenyl)methylidene]-3-oxobutanoate | HCID 299600 | — |
| 반응물 | HCID 11174576 | HCID 11174576 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Phthalimidoamlodipine | HCID 9871958 | 70% |
반응 단계
24.0 g (75.4 mmoles) of ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and 18.9 g (79.2 mmoles) of methyl 2-(2-chlorobenzylidene)acetoacetate in 64 ml of ethanol were heated under reflux for 20 hours. The reaction mixture was diluted with 56 ml of ethanol and was cooled to crystallise the product. 14.2 g (yield 70%) of 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(2-phthalimidoethoxy)methyl-1,4-dihydropyridine were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06603006B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-3435c4404c6640cf91f4a87b281daaab |
| 출처 메모 | uspto-grants-2003_08 |