Methyl 2-[(2-chlorophenyl)methylidene]-3-oxobutanoate → Phthalimidoamlodipine

HRID 394821

반응식

HRID 394821 반응식
[NH2:1]/[C:2](/[CH2:9][O:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])=[CH:3]\[C:4]([O:6][CH2:7][CH3:8])=[O:5].[Cl:24][C:25]1[CH:39]=[CH:38][CH:37]=[CH:36][C:26]=1[CH:27]=[C:28]([C:33]([CH3:35])=O)[C:29]([O:31][CH3:32])=[O:30]>C(O)C>[Cl:24][C:25]1[CH:39]=[CH:38][CH:37]=[CH:36][C:26]=1[CH:27]1[C:28]([C:29]([O:31][CH3:32])=[O:30])=[C:33]([CH3:35])[NH:1][C:2]([CH2:9][O:10][CH2:11][CH2:12][N:13]2[C:14](=[O:23])[C:15]3=[CH:22][CH:21]=[CH:20][CH:19]=[C:16]3[C:17]2=[O:18])=[C:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

참가 물질

4

반응물 2

HCID 299600Methyl 2-[(2-chlorophenyl)methylidene]-3-oxobutanoateHCID 11174576HCID 11174576, 화합물

생성물 1

HCID 9871958Phthalimidoamlodipine수율 70%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

24.0 g (75.4 mmoles) of ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and 18.9 g (79.2 mmoles) of methyl 2-(2-chlorobenzylidene)acetoacetate in 64 ml of ethanol were heated under reflux for 20 hours. The reaction mixture was diluted with 56 ml of ethanol and was cooled to crystallise the product. 14.2 g (yield 70%) of 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(2-phthalimidoethoxy)methyl-1,4-dihydropyridine were obtained.

후처리

  1. temperatureunder reflux for 20 hours
  2. temperaturewas cooled
  3. customto crystallise the product

출처 및 근거

ORD 기록
ord-3435c4404c6640cf91f4a87b281daaab
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06603006B2

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