2,5-Dimethoxybenzaldehyde → 2,5-Dimethoxy-4'-prop-2-enyloxychalcone

HRID 394969노트

반응식

HRID 394969 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH:12]=[CH2:13])=[CH:6][CH:5]=1)=[O:3].[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:17]=1[CH:18]=O>>[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:17]=1[CH:18]=[CH:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH:12]=[CH2:13])=[CH:6][CH:5]=1)=[O:3]

참가 물질

3

반응물 2

HCID 667262,5-DimethoxybenzaldehydeHCID 959691-(4-(2-Propen-1-yloxy)phenyl)ethanone

생성물 1

HCID 541484062,5-Dimethoxy-4'-prop-2-enyloxychalcone수율 83%

실험 절차

1.76 g (10 mmol) of 4-allyloxyacetophenone and 1.66 g (10 mmol) of 2,5-dimethoxy-benzaldehyde were under an inert atmosphere (argon) dissolved in 10 ml of dry freshly distilled ethanol, and 100 mg of sodium hydroxide was added to the solution. The mixture was left under stirring for 2.5 h and filtered. The precipitate was recrystallized from methanol to give 2.50 g (83%) of 2,5-dimethoxy-4′-prop-2-enyloxychalcone, m.p. 86-87° C.

후처리

  1. dissolutiondissolved in 10 ml
  2. dry with materialof dry freshly distilled ethanol, and 100 mg of sodium hydroxide
  3. additionwas added to the solution
  4. waitThe mixture was left
  5. filtrationfiltered
  6. customThe precipitate was recrystallized from methanol

출처 및 근거

ORD 기록
ord-c1cd1a4b4781411cbfa4335d7cded9f1
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06603046B1

반응 노트

불러오는 중…