Triphenylphosphane dibromide → 4-Bromo-3-chloro-6,7-dimethoxyquinoline

HRID 394986

반응식

HRID 394986 반응식
[Br-:1].[Br-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:22][C:23]1[CH:24]=[N:25][C:26]2[C:31]([C:32]=1O)=[CH:30][C:29]([O:34][CH3:35])=[C:28]([O:36][CH3:37])[CH:27]=2>C(#N)C>[Br:1][C:32]1[C:31]2[C:26](=[CH:27][C:28]([O:36][CH3:37])=[C:29]([O:34][CH3:35])[CH:30]=2)[N:25]=[CH:24][C:23]=1[Cl:22]

참가 물질

4

반응물 2

HCID 12890784Triphenylphosphane dibromideHCID 178486799HCID 178486799, 화합물

생성물 1

HCID 224697664-Bromo-3-chloro-6,7-dimethoxyquinoline수율 83.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
20 °C

실험 절차

19 g of triphenylphosphine dibromide were added to a solution of 5.39 g of 3-chloro-4-hydroxy-6,7-dimethoxyquinoline in 270 cm3 of acetonitrile, with stirring and at a temperature in the region of 20° C. The reaction mixture was heated at about 80° C. for 8.25 hours. After cooling to a temperature in the region of 20° C., the insoluble material was filtered off. 5.67 g of 4-bromo-3-chloro-6,7-dimethoxyquinoline were obtained in the form of a gray solid.

후처리

  1. temperatureThe reaction mixture was heated at about 80° C. for 8.25 hours
  2. temperatureAfter cooling to a temperature in the region of 20° C.
  3. filtrationthe insoluble material was filtered off

출처 및 근거

ORD 기록
ord-cebb2d1255fa4bd0af82db8596e0f4cc
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06603005B2

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