홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ethyl Acetate → 2,2,4,4-Tetramethyl-chroman-6-carboxylic acid 4-(tert-butoxycarbonylmethyl)phenyl ester

HRID 395068
노트
인쇄 미리보기

반응식

HRID 395068 반응식
[CH3:1][C:2]1([CH3:17])[CH2:11][C:10]([CH3:13])([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=2)[O:3]1.C(OC1C=CC(O)=CC=1C(C)(C)C)(=O)C.[C:33]([O:37][C:38](=[O:47])[CH2:39][C:40]1[CH:45]=[CH:44][C:43](O)=[CH:42][CH:41]=1)([CH3:36])([CH3:35])[CH3:34].C(OCC)(=O)C>S(Cl)(Cl)=O.CCCCCC>[C:33]([O:37][C:38]([CH2:39][C:40]1[CH:41]=[CH:42][C:43]([O:15][C:14]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[O:3][C:2]([CH3:17])([CH3:1])[CH2:11][C:10]3([CH3:12])[CH3:13])=[O:16])=[CH:44][CH:45]=1)=[O:47])([CH3:36])([CH3:34])[CH3:35]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 8857Ethyl AcetateHCID 157287092,2,4,4-Tetramethyl-3,4-dihydro-2H-1-benzopyran-6-carboxylic acidHCID 15932404Tert-butyl 2-(4-hydroxyphenyl)acetateHCID 23442872t-Butyl-4-hydroxy-phenyl acetate

생성물 1

HCID 695485442,2,4,4-Tetramethyl-chroman-6-carboxylic acid 4-(tert-butoxycarbonylmethyl)phenyl ester수율 55%

시약·촉매·용매

2
HCID 8058Hexane용매HCID 24386Thionyl Chloride용매

실험 절차

A solution of 2,2,4,4-tetramethyl chroman-6-carboxylic acid (0.1 g, 0.43 mmol) in thionyl chloride (10 mL) was refluxed for 2 h. The thionyl chloride was evaporated under reduced pressure and the residue was dissolved in 5 mL of dichloromethane and treated with triethyl amine (5 mL) followed by tert-butyl-4-hydroxy phenyl acetate (Reagent E, 0.088 g, 0.427 mmol). After 0.5 h, the reaction mixture was subjected to flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent to afford the title compound (0.1 g, 55%).

후처리

  1. customThe thionyl chloride was evaporated under reduced pressure
  2. dissolutionthe residue was dissolved in 5 mL of dichloromethane
  3. additiontreated with triethyl amine (5 mL)

출처 및 근거

ORD 기록
ord-e49c6fd32abb41019045f0b4d280d828
출처 데이터셋
uspto-grants-2003_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06603019B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트