Hydrogen Peroxide → 3-Fluoroisonicotinic acid 1-oxide

HRID 39508

반응식

HRID 39508 반응식
[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH:11]O>C(O)(=O)C>[F:1][C:2]1[CH:10]=[N+:9]([O-:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 3453613-Fluoropyridine-4-carboxylic acid

생성물 1

HCID 576496373-Fluoroisonicotinic acid 1-oxide

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
75 °C

실험 절차

To a solution of 3-fluoroisonicotinic acid (5.0 g, 35.33 mmol) in acetic acid (25 ml) was added hydrogen peroxide (6 ml). The reaction mixture was stirred at 70-80° C. overnight. The solvent was removed to obtain 5.5 g of 3-fluoroisonicotinic acid 1-oxide in quantitative yield.

후처리

  1. customThe solvent was removed

출처 및 근거

ORD 기록
ord-eefb4f777a6c4d60abf2477d1e1f9e78
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524911B2

연결된 노트

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