Potassium Carbonate → 1-Ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene

HRID 395129노트

반응식

HRID 395129 반응식
[CH2:1]([O:8][C:9]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]#[C:19][Si](C)(C)C)=[CH:14][C:13]=2[CH2:24][CH3:25])[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([C:9]2([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:10]2)=[C:13]([CH2:24][CH3:25])[CH:14]=1)#[CH:19]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 22568833[4-(1-Benzyloxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane2회

생성물 1

HCID 225689831-Ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Using General Procedure E; [4-(1-benzyloxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane (Intermediate 89, 240 mg, 0.69 mmol) in methanol (6 mL) was treated with potassium carbonate (10.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (190 mg, 99%) was used directly in the next reaction. 1H NMR (CDCl3) δ: 7.43-7.15 (8H, m), 4.27 (2H, s), 3.08 (1H, s), 3.01 (2H, q, J=7.6 Hz), 1.26 (3H, t, J=7.6 Hz), 1.22 (2H, m), 0.92 (2H, m).

출처 및 근거

ORD 기록
ord-a6fffd791039464fb31dfd06886b9df9
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06603019B2

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