2-Methoxyethylamine → 3-(2-Fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethyl)-isonicotinamide

HRID 39524

반응식

HRID 39524 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.C[O:20][CH2:21][CH2:22][NH2:23]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:23][CH2:22][CH2:21][OH:20])=[O:14]

참가 물질

3

반응물 2

HCID 80182-MethoxyethylamineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2회

생성물 1

HCID 576496543-(2-Fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethyl)-isonicotinamide

실험 절차

3-(2-Fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethyl)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.45 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.60 mmol of 2-methoxy-ethylamine. LC/MS [3.42 min; 402 (M+1)]

후처리

  1. customLC/MS [3.42 min; 402 (M+1)]

출처 및 근거

ORD 기록
ord-d20ec6959203455cb629f9c31c5742cb
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524911B2

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