1-Aminopiperidine → 3-[(2-fluoro-4-iodophenyl)amino]-N-piperidin-1-ylisonicotinamide

반응식

[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[N:19]1([NH2:25])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:25][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)=[O:14]

참가 물질

반응물 2

HCID 166581-Aminopiperidine

HCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2회

생성물 1

HCID 115030773-[(2-fluoro-4-iodophenyl)amino]-N-piperidin-1-ylisonicotinamide

실험 절차

3-[(2-fluoro-4-iodophenyl)amino]-N-piperidin-1-ylisonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.30 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.47 mmol of piperidin-1-ylamine LC/MS [8.81 min; 441 (M+1)]

출처 및 근거

ORD 기록: ord-cabaa7daad1640708d7117fb6d6d67f7
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08524911B2

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