참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 5-Fluoro-2-nitrobenzonitrile | HCID 3756467 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 5-(4-Methylpiperazinyl)-2-nitrobenzenecarbonitrile | HCID 16102059 | — |
반응 단계
5-Fluoro-2-nitrobenzenecarbonitrile (1.02 eq) and N-methylpiperazine, (1.0 eq) were dissolved in NMP. Triethylamine (2.1 eq) was added, and the resulting solution heated at 100° C. for 1 hour. The solution was cooled to room temperature and poured into H2O. A precipitate formed which was filtered to yield the desired product as a green solid. LC/MS m/z 247.3 (MH+), Rf 1.46 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06605617B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_08 |
|---|
| ORD ID | ord-53df55582943408cafa0c461ad6b6887 |
|---|
| 출처 메모 | uspto-grants-2003_08 |
|---|
