[CH2:1]([C:6]1([S:13]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[S:10][C:9](=[O:11])[NH:8][C:7]1=[O:12])[CH2:2][CH2:3][C:4]#[CH:5].[CH2:23](O)[CH2:24][CH2:25][C:26]#[CH:27].C([NH:31]CC)C>ClCCl.[Cu]I>[N:31]1[CH:27]=[CH:26][CH:25]=[C:24]([C:5]#[C:4][CH2:3][CH2:2][CH2:1][C:6]2([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[S:10][C:9](=[O:11])[NH:8][C:7]2=[O:12])[CH:23]=1A solution of 5-pent-4-ynyl-5-(toluene-4-sulfonyl)-thiazolidine-2,4-dione(1.0 mmol), 4-pentyn-1-ol (1.0 mmol), bistriphenylphosphine(Pd II) chloride (0.20 mmol), and copper(I) iodide (0.10 mmol) in 50 ml of diethylamine was stirred under nitrogen for three days. This was diluted with dichloromethane and the product was purified by chromatography to give the title compound as a light beige solid, mp 173-176° C., THEORY: C, 57.95, H, 4.38 N, 6.76. FOUND: C, 57.68, H, 4.35, N, 6.70.
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