Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Dihydrofuran → Methyl 2-(Difluoromethyl)-4-(2-methylpropyl)-5-[(tetrahydro-2-furyl)thio]-6-(trifluoromethyl)-3-pyridinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Dihydrofuran | HCID 70934 | — |
| 반응물 | Methyl 2-(difluoromethyl)-4-isobutyl-5-mercapto-6-(trifluoromethyl)-3-pyridinecarboxylate | HCID 9974711 | — |
| 촉매 | 2-Methylbenzenesulfonic acid | HCID 6925 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Methyl 2-(Difluoromethyl)-4-(2-methylpropyl)-5-[(tetrahydro-2-furyl)thio]-6-(trifluoromethyl)-3-pyridinecarboxylate | HCID 22668859 | 68% |
반응 단계
A mixture of 7.07 g (0.021 mol) of compound 7, 2.92 g (0.042 mol) of dihydrofuran, and catalytic toluenesulfonic acid (9 mg) in 80 ml of ether was stirred overnight. The reaction mixture was concentrated in vacuo, and the residue was purified by HPLC (20% EtOAc in hexane) to give 5.82 g (68%) of the desired product as a yellow oil, n25D 1.5803.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06605624B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-a9da341029bb48f9be78671f29ee9d6a |
| 출처 메모 | uspto-grants-2003_08 |