Ethyl 2-chloroisonicotinate → Ethyl 2-(3,5-dimethoxy-4-isopropoxyphenyl)isonicotinate

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[C:7]([O:13][CH3:14])[C:8]=1[O:9][CH:10]([CH3:12])[CH3:11].Cl[C:19]1[CH:20]=[C:21]([CH:27]=[CH:28][N:29]=1)[C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:19]2[CH:20]=[C:21]([CH:27]=[CH:28][N:29]=2)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]=[C:7]([O:13][CH3:14])[C:8]=1[O:9][CH:10]([CH3:12])[CH3:11]

참가 물질

반응물 2

HCID 2762942Ethyl 2-chloroisonicotinate

HCID 224855944-Isopropoxy-3,5-dimethoxyphenylboronic acid

생성물 1

HCID 22557851Ethyl 2-(3,5-dimethoxy-4-isopropoxyphenyl)isonicotinate

실험 절차

To a solution of 3,5-dimethoxy-4-isopropoxyphenylboronic acid (1.23 g) and ethyl 2-chloroisonicotinate (0.95 g) were condensed in the same manner as described in Preparation Example 1 to give the title compound.

후처리

customcondensed in the same manner
customas described in Preparation Example 1

출처 및 근거

ORD 기록: ord-6547942edf7c49d3a2d5675c746f0235
출처 데이터셋: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06605620B1

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