Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-{4-[(4-hydroxyphenyl)(methyl)sulfamoyl]phenyl}acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | N-Acetylsulfanilyl chloride | HCID 8481 | — |
| 반응물 | p-(N-methylamino)phenol sulfate | HCID 10198132 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-{4-[(4-hydroxyphenyl)(methyl)sulfamoyl]phenyl}acetamide | HCID 2998367 | — |
반응 단계
4-Methylaminophenol sulfate and equivalent 4-acetamidobenzenesulfonyl chloride and double equivalent triethylamine were reacted in ethanol at room temperature for 4 hours. After the solvent was removed in vacuo, the residue was extracted with diethyl ether. The ether layer was washed successively with 2 N hydrochloric acid, saturated aqueous NaHCO3 solution and water, then dried over anhydrous Na2SO4 The solvent was removed and the residue was recrystallized from ethanol to give N-(4-hydroxyphenyl)-N-methyl-4-acetamidobenzenesulfonamide, mp 202-203° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06605635B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-c49085fcab17466c95941101e1a3525b |
| 출처 메모 | uspto-grants-2003_08 |