Phenylmethylsulfonyl Fluoride → Potassium alpha-toluenesulfonate

HRID 3956

반응식

HRID 3956 반응식
[C:1]1([CH2:7][S:8](F)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[Si](C)(C)[O-:14].[K+:17]>O1CCCC1>[C:1]1([CH2:7][S:8]([O-:10])(=[O:14])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[K+:17]

참가 물질

4

반응물 2

HCID 4784Phenylmethylsulfonyl FluorideHCID 23668039Potassium trimethylsilanolate

생성물 1

HCID 23666503Potassium alpha-toluenesulfonate수율 58.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

The procedure of Example 1 was followed using α-toluenesulfonyl fluoride (2.0 g, 11.5 mmol) in dry tetrahydrofuran (15 mL), potassium trimethylsilanolate (1.48 g, 11.5 mmol) and dry tetrahydrofuran (45 mL), and 2 h of heating at reflux. Potassium α-toluenesulfonate (1.41 g, 58% yield) was isolated as a white solid: 1H NMR (D2O) δ 4.1 (s, CH2, 2H), 7.4 ppm (s, Ar--H's, 5H).

후처리

  1. temperatureof heating
  2. temperatureat reflux

출처 및 근거

ORD 기록
ord-38f5d19da7814e449f56363466a7475c
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723016

연결된 노트

불러오는 중…