3-Chloropropylamine → N-(3-chloropropyl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

HRID 39575

반응식

HRID 39575 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[Cl:19][CH2:20][CH2:21][CH2:22][NH2:23]>>[Cl:19][CH2:20][CH2:21][CH2:22][NH:23][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1]

참가 물질

3

반응물 2

HCID 846293-ChloropropylamineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2회

생성물 1

HCID 11633443N-(3-chloropropyl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

실험 절차

N-(3-chloropropyl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 1 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 1.3 mmol of 3-chloropropylamine. LC/MS [9.24 min; 434 (M+1)]

후처리

  1. customLC/MS [9.24 min; 434 (M+1)]

출처 및 근거

ORD 기록
ord-4a6d5745b26947f79e5869e663758dab
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524911B2

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