Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(2-Aminophenyl)-4-methoxybenzamide → N1-(4-Methoxybenzoyl)-N2-(5-chlorobenzofuran-2-ylcarbonyl)-1,2-benzenediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(2-Aminophenyl)-4-methoxybenzamide | HCID 785232 | — |
| 반응물 | 5-Chloro-1-benzofuran-2-carboxylic acid | HCID 937838 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N1-(4-Methoxybenzoyl)-N2-(5-chlorobenzofuran-2-ylcarbonyl)-1,2-benzenediamine | HCID 21352766 | 60.1% |
반응 단계
To a solution of N1-(4-methoxybenzoyl)-1,2-benzenediamine (200 mg, 0.826 mmol) in methylene chloride (5 mL) was added 5-chlorobenzofuran-2-carboxylic acid (162 mg, 0.826 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (316 mg, 1.65 mmol), and 4-dimethylaminopyridine (10 mg, 0.083 mmol), The resulting solution was stirred at room temperature for 6 h. The resulting precipitate was collected via vacuum filtration to provide 209 mg (60%) of the title compound as an amorphous off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06605626B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-7d9cc5b1f30945c98294dd9775630341 |
| 출처 메모 | uspto-grants-2003_08 |