Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Chlorofuran-2-carboxylic acid → N1-(5-Chlorofuran-2-ylcarbonyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2-benzenediamine Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Chlorofuran-2-carboxylic acid | HCID 234853 | — |
| 반응물 | N1-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl)-1,2-benzenediamine | HCID 86585755 | — |
| 생성물 | N1-(5-Chlorofuran-2-ylcarbonyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2-benzenediamine Hydrochloride | HCID 86585766 | 22% |
반응 단계
Using the procedure described in Example 168, N1-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2-benzenediamine (0.61 mmol) and 5-chloro-2-furancarboxylic acid (1.2 mmol), purifying with RPHPLC Method A, yielded 57 mg (22%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06605626B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-f4fd0a8ff60e4cdc9c2aaeab370ef6ef |
| 출처 메모 | uspto-grants-2003_08 |