HCID 6481530, 화합물 → HCID 18174570, 화합물

HRID 395840노트

반응식

HRID 395840 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:17])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH2:16])[CH:5]=[CH:6][CH:7]=1.[N:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:32][CH2:31][CH:27]([C:28]([Cl:30])=[O:29])[CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[ClH:30].[N:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:25][CH2:26][CH:27]([C:28]([NH:16][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[O:17])=[O:29])[CH2:31][CH2:32]2)=[CH:20][CH:19]=1

참가 물질

3

반응물 2

HCID 6481530HCID 6481530, 화합물HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chloride

생성물 1

HCID 18174570HCID 18174570, 화합물수율 68%

실험 절차

Using the procedure described in Example-138, N-(3-fluorophenyl)-2-aminobenzamide (1.3 mmol) and N-(4-pyridyl)isonipecotoyl chloride (2.6 mmol), purifying with RPHPLC Method D, yielded 402 mg (68%) of the title compound.

후처리

  1. custompurifying with RPHPLC Method D

출처 및 근거

ORD 기록
ord-e700d7d030144fe79b5370926ff410d4
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06605626B2

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