Methanol → Methyl 2,2-dimethylpent-4-enoate

HRID 395897노트

반응식

HRID 395897 반응식
[CH3:1][C:2]([CH3:9])([CH2:6][CH:7]=[CH2:8])[C:3]([OH:5])=[O:4].[CH3:10]O.S(=O)(=O)(O)O>C1(C)C=CC=CC=1>[CH3:1][C:2]([CH3:9])([CH2:6][CH:7]=[CH2:8])[C:3]([O:5][CH3:10])=[O:4]

참가 물질

5

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 1400652,2-Dimethyl-4-pentenoic acid

생성물 1

HCID 11768679Methyl 2,2-dimethylpent-4-enoate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2,2-Dimethyl-4-pentenoic acid (15 g, 0.117 mol) was mixed with 70 mL anhydrous methanol and 50 mL toluene. Concentrated sulfuric acid (0.1 mL) was added. The solution was refluxed for 24 h. Solvents were then removed. The crude product was distilled under reduced pressure to gave 6 g pure product. 1H NMR(CDCl3) δ1.28(s, 6H, —CMe2—); 2.37(d, 2H, CH2═CHCH2—); 3.77(s, 3H, —CO2Me); 5.15(m, 2H, CH2═CH—); 5.84(m, 1H, CH2═CH—)

후처리

  1. temperatureThe solution was refluxed for 24 h
  2. customSolvents were then removed
  3. distillationThe crude product was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-b28d5c9c0660451397b170954272443c
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06605679B1

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