Chloroform → 4-(2-(4-fluoro-N-benzoylamino)benzoyl)pyridine

참여 물질

역할	이름	HCID	투입량
반응물	Chloroform	HCID 6212	—
반응물	Triethylamine	HCID 8471	—
반응물	4-Fluorobenzoyl chloride	HCID 67879	—
반응물	(2-Aminophenyl)(pyridin-4-yl)methanone	HCID 14005182	—
용매	Water	HCID 962	—
생성물	4-(2-(4-fluoro-N-benzoylamino)benzoyl)pyridine	HCID 18175249	—

반응 단계

4-Fluorobenzoyl chloride (78.0 mg, 0.55 mmol) was added to 4-(2-aminobenzoyl)pyridine (12) (100 mg, 0.50 mmol), triethylamine (0.35 mL, 2.52 mL), and chloroform (5.0 mL) at 23° C. under argon. After 24 h at 23° C., the reaction was poured into water (50 mL), extracted with ethyl acetate (3×50 mL), and dried (MgSO4). After concentration in vacuo, the residue was purified by flash chromatography (ethyl acetate:methylene chloride 1:1) to afford 4-(2-(4-fluoro-N-benzoylamino)benzoyl)pyridine (14): Mass Spectrum (CI) 321 (MH+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06605634B2
출처 데이터셋	uspto-grants-2003_08
ORD ID	ord-63470f7b151e47ca901cfe17538a4025
출처 메모	uspto-grants-2003_08