2-Amino-2-ethyl-1,3-propanediol → N-(1,1-Bis-hydroxymethyl-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

HRID 39598

반응식

HRID 39598 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[NH2:19][C:20]([CH2:25][CH3:26])([CH2:23][OH:24])[CH2:21][OH:22]>>[OH:22][CH2:21][C:20]([NH:19][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1])([CH2:23][OH:24])[CH2:25][CH3:26]

참가 물질

3

반응물 2

HCID 82822-Amino-2-ethyl-1,3-propanediolHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2회

생성물 1

HCID 11518227N-(1,1-Bis-hydroxymethyl-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

실험 절차

N-(1,1-Bis-hydroxymethyl-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.33 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.47 mmol of 2-amino-2-ethyl-propane-1,3-diol. LC/MS [5.93 min; 460 (M+1)]

후처리

  1. customLC/MS [5.93 min; 460 (M+1)]

출처 및 근거

ORD 기록
ord-fb86a7932c7a43d8b6f7464fc14498a0
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524911B2

연결된 노트

불러오는 중…