5-(Benzyloxy)-2-nitrobenzaldehyde → 1-[5-(Benzyloxy)-2-nitrophenyl]-3-methyl-2-buten-1-ol

HRID 396124노트

반응식

HRID 396124 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:17]([O-:19])=[O:18])=[C:13]([CH:16]=1)[CH:14]=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][C:21]([CH3:25])=[CH:22][Mg]Br>C1COCC1>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:17]([O-:19])=[O:18])=[C:13]([CH:14]([OH:15])[CH:20]=[C:21]([CH3:25])[CH3:22])[CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 38498355-(Benzyloxy)-2-nitrobenzaldehydeHCID 178448304HCID 178448304, 화합물

생성물 1

HCID 230030561-[5-(Benzyloxy)-2-nitrophenyl]-3-methyl-2-buten-1-ol수율 51%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

In an analogous manner to the procedure of Example II, 2.88 g (11.20 mmol) of 5-benzyloxy-2-nitrobenzaldehyde in 30 ml of THF are reacted at −78° C. with 31.7 ml (15.67 mmol) of a 0.5 M 2-methyl-propenylmagnesium bromide soln in THF to give 1.8 g (51%) of 1-[5-(benzyloxy)-2-nitrophenyl]-3-methyl-2-buten-1-ol.

출처 및 근거

ORD 기록
ord-113c251b6dde4568bbf79513b5ca4a21
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608049B2

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