1-Benzyl-3-ethyl-4-hydroxypiperidine → 3-Ethylpiperidin-4-ol
반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH:10]([CH2:15][CH3:16])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[Pd+2].[OH-]>[CH2:15]([CH:10]1[CH:11]([OH:14])[CH2:12][CH2:13][NH:8][CH2:9]1)[CH3:16]참가 물질
5
실험 절차
A mixture of 1-benzyl-3-ethyl-4-hydroxypiperidine (5.0 g, 22.0 mmole) and palladium hydroxide (1.5 g) in methanol (100 ml) was stirred at 5.0 g, 22.0 mmole) and palladium hydroxide (1.5 g) in methanol (100 ml) was stirred at 50-55° C. in hydrogen atmosphere (1 atm.) for 20 hr. The catalyst was filtered off, washed with methanol, and filtrate was concentrated to dryness to give 3-ethyl-4-hydroxypiperidine as oil. Yield 2.9 g (94%), C7H15NO, m/z 130 (M+1).
후처리
- filtrationThe catalyst was filtered off
- washwashed with methanol, and filtrate
- concentrationwas concentrated to dryness
출처 및 근거
- ORD 기록
- ord-8eda4e99072d423ca3f7f36185454433
- 출처 데이터셋
- uspto-grants-2003_08
- 특허 번호
- US06608078B2
반응 노트
불러오는 중…