Oxalyl chloride → 2-(2-furyl)quinoline-4-carbonyl Chloride

HRID 396344노트

반응식

HRID 396344 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]1[CH:21]=C(C(O)=O)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1>C(Cl)Cl>[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]1[CH:21]=[C:1]([C:2]([Cl:4])=[O:3])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 6976402-(Furan-2-yl)quinoline-4-carboxylic acid

생성물 1

HCID 106349112-(2-furyl)quinoline-4-carbonyl Chloride수율 100.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
-10 °C

실험 절차

5.2 ml (60.4 mmol) of oxalyl chloride were dissolved in 70 ml of CH2Cl2. The solution was cooled at −10° C. and 8.5 g (35.5 mmol) of 2-(2-furyl)quinoline-4-carboxylic acid were added portionwise. The reaction mixture was left overnight at room temperature and then evaporated to dryness to yield 9.2 g of the title compound, used without further purification.

후처리

  1. customevaporated to dryness

출처 및 근거

ORD 기록
ord-40299ccc2b3b4906ba7cccf3ddcf187b
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608083B1

반응 노트

불러오는 중…