Methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate → Methyl[6-chloro-2-[4-(methylsulfonylamino)benzoyl]-1h-indol-3-yl]acetate
반응식
[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[C:8]([O:10][CH3:11])=[O:9])=[C:4]([NH:14]S(C2C=CC=CC=2)(=O)=O)[CH:3]=1.[CH3:24][S:25]([NH:28][C:29]1[CH:38]=[CH:37][C:32]([C:33](=[O:36])[CH2:34]Br)=[CH:31][CH:30]=1)(=[O:27])=[O:26]>>[CH3:11][O:10][C:8](=[O:9])[CH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:13][CH:12]=2)[NH:14][C:34]=1[C:33](=[O:36])[C:32]1[CH:31]=[CH:30][C:29]([NH:28][S:25]([CH3:24])(=[O:27])=[O:26])=[CH:38][CH:37]=1참가 물질
3
실험 절차
The title compound was prepared according to the procedure described in Example 8 (Method B) from methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate (step 1 of Example 8, Method A) and 4-(methylsulfonylamino)phenacyl bromide*.
출처 및 근거
- ORD 기록
- ord-3695724a4550449891d0cd02ae51c460
- 출처 데이터셋
- uspto-grants-2003_08