Diketene → HCID 23004067, 화합물

HRID 396625노트

반응식

HRID 396625 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[CH:17]=2)[CH2:12]1>C1COCC1>[CH3:22][O:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][C:15]=1[O:23][CH3:24])[CH2:12][N:11]([CH2:10][CH2:9][CH2:8][NH:7][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:20][CH2:19]2

참가 물질

4

반응물 2

HCID 12661DiketeneHCID 230040563,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinepropanamine

생성물 1

HCID 23004067HCID 23004067, 화합물수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Diketene (1.41 mL, 18.3 mmol, 1.50 equiv) was added at 0° C. to a stirred solution of 2-(3-aminopropyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (3.05 g, 12.2 mmol, 1.00 equiv) in anhydrous THF (30 mL) under argon, and stirring was continued at room temperature for 1.5 hours. The mixture was concentrated and the residual oil washed with hexane (2×100 mL) to give 4.07 g (100%) of brown oil, which was characterized spectroscopically and used for the next reaction without purification.

후처리

  1. concentrationThe mixture was concentrated
  2. washthe residual oil washed with hexane (2×100 mL)

출처 및 근거

ORD 기록
ord-c4096cc82df548e383c6d5b082eaf76b
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608086B2

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